3/6/2023 0 Comments Destiny 2 infuse calculator![]() Lets do a quick calculation on a hypothetical hypoglycaemic patient who presents to triage with a BSL of 0 mmol/L. ![]() The increase in intravascular volume is 1.5% - outside the volume receptor sensitivity threshold. The intravascular compartment volume increases by 80ml – from 5000ml to 5080ml. Vasopressin release in decreased, and over its next 3 halflives the urinary excretion of free water gradually increases. The change in osmolality is 2.3% - within the osmoreceptor sensitivity threshold. The osmolality decreases by about 6.5mmol/L – from 290 to 283.5. Osmoreceptor responseĪll the compartments become slightly diluted, to an equal degree (because the proportional gain of water is the same). The numbers below do not contain the extra 30ml of water, because the contribution of such minutae is confusing and bewildering. Thus, from 278 mmol of dextrose the body gains an additional 1668 mmol of H2O, or about 30ml. Not only does the body gain 1 litre of solvent water from the actual bag of dextrose each molecule of dextrose itself is metabolised into 6 molecules of water and 6 molecules of CO2. It distributes itself according to its normal compartment proportions that is to say, 2/3rds will go into cells within the hour, and of the remaining third 75% will join the interstitial fluid. This, needless to say, is not going to hang around in the intravascular space. Usually, plasma half-life of a dextrose bolus is no greater than 15 minutes, in the absence of diabetes. The dextrose is taken up rapidly into the cells. What am I giving? The litre of 5% dextrose is 278 mmol of dextrose (d-glucose).
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